Improving treatment for spina bifida in unborn babies
Engineering the fetal environment for in utero treatment of spina bifida bone defect
This study is exploring a new way to help babies with spina bifida by using special cells from the placenta during surgery before they are born, with the goal of repairing their spinal cord and helping their bones grow stronger for better movement later on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11029300 on NIH RePORTER |
What this research studies
This research focuses on enhancing the treatment of spina bifida, a serious birth defect, by using placental stem cells during in utero surgery. The approach aims to not only repair the spinal cord but also regenerate the surrounding bone structure to support long-term motor function. By utilizing the natural regenerative capabilities of the fetal environment, the study seeks to improve outcomes for children affected by this condition. The research will involve advanced bioengineering techniques to create a supportive environment for tissue regeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are unborn babies diagnosed with myelomeningocele, the most severe form of spina bifida.
Not a fit: Patients who have already been born with spina bifida or those with other unrelated congenital conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve mobility and quality of life for children born with spina bifida.
How similar studies have performed: Previous research has shown promise in using stem cells for in utero treatments, but this specific approach to bone regeneration in spina bifida is novel.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Hao, Dake — University of California at Davis
- Study coordinator: Hao, Dake
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.