Improving treatment for pancreatic cancer in African American patients
Pilot Project 5
This study is looking at a new way to treat pancreatic cancer, especially for African American patients, by testing a modified chemotherapy drug that might work better than the usual treatments, using tiny lab-grown models made from patient cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10931550 on NIH RePORTER |
What this research studies
This research focuses on pancreatic ductal adenocarcinoma (PDAC), a highly aggressive cancer with low survival rates, particularly among African American individuals. The study aims to enhance the effectiveness of a modified chemotherapy drug, 4-(N)-stearoylGem, which is designed to improve drug delivery and reduce resistance in cancer cells. By using patient-derived organoid models, the research will evaluate how well this new treatment works compared to standard therapies. The goal is to provide a more effective treatment option for patients who currently have limited choices.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American individuals diagnosed with pancreatic ductal adenocarcinoma.
Not a fit: Patients with other types of cancer or those not of African American descent may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment outcomes and survival rates for African American patients with pancreatic cancer.
How similar studies have performed: Previous research has shown promise in using modified chemotherapy approaches for pancreatic cancer, indicating potential for success in this novel application.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Rogers, Sherise C. — University of Florida
- Study coordinator: Rogers, Sherise C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.