Improving treatment for pancreatic cancer by targeting a specific enzyme
Optimizing anti-wild-type IDH1 therapy in pancreatic cancer
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11038046
This study is looking at how a specific enzyme helps pancreatic cancer cells survive and is testing FDA-approved drugs that block this enzyme to see if they can make current treatments work better for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11038046 on ClinicalTrials.gov |
What this research studies
This research focuses on pancreatic ductal adenocarcinoma (PDAC), a highly lethal cancer with few effective treatments. The team is investigating how the enzyme wild-type IDH1 supports the survival of PDAC cells in a challenging environment. By using FDA-approved drugs that inhibit this enzyme, the researchers aim to enhance the effectiveness of existing therapies, potentially leading to better outcomes for patients. The study will explore various strategies, including pharmacological and dietary approaches, to optimize treatment and improve patient responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma, particularly those with wild-type IDH1 expression.
Not a fit: Patients with other types of cancer or those whose tumors do not express wild-type IDH1 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with pancreatic cancer.
How similar studies have performed: Previous research has shown promise in targeting wild-type IDH1 in pancreatic cancer, indicating that this approach could be effective.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WINTER, JORDAN M — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: WINTER, JORDAN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer research