Improving treatment for chronic pelvic pain in men
Official title: Optimizing Dual Therapy for Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Funded at Dolor Therapeutics, LLC · NIH-10918611 · Data updated 2026-11-12
This study is looking to create a new oral medication to help men under 50 who suffer from chronic prostatitis/chronic pelvic pain syndrome, by combining two types of medicine that have shown promise, and it will first test these new formulas in dogs to find the best one before trying it in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dolor Therapeutics, LLC NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $318,488 |
| NIH project number | 1R41DK139835-01 |
| Project ID | NIH-10918611 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men under 50 who are experiencing chronic pelvic pain or prostatitis.
✕Less likely to help
Patients who do not have chronic prostatitis or chronic pelvic pain syndrome may not benefit from this research.
What this research studies
This research focuses on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), a common condition affecting men under 50. The study aims to develop a new oral medication that combines a mast cell stabilizer and a histamine receptor antagonist, which has shown promise in previous pilot studies. By enhancing the absorption of these medications through optimized formulations, the goal is to create a more effective and easier treatment option for patients. The research will involve testing these formulations in dogs to determine the best option before moving to human trials.
Why it matters
Potential benefit: If successful, this research could lead to a more effective and convenient treatment for men suffering from chronic pelvic pain.
How similar studies have gone: Previous pilot studies have shown success with similar approaches, indicating potential for this research to build on those findings.
Where this research is happening
-
Dolor Therapeutics, LLC
Chicago, United States Active
Researchers
- Principal investigator: Sargent, William Q — Dolor Therapeutics, LLC
- Study coordinator: Sargent, William Q
Related research
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-
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A brief behavioral treatment for chronic pelvic pain
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Using glial cells to reduce visceral pain in bladder conditions
This study is looking at how certain cells in the nervous system can be activated to help reduce the pain that comes with chronic pelvic pain syndrome, especially for those dealing with bladder issues, and it aims to find new treatment options that could eventually help people like you.
-
Investigating the role of food-specific antibodies in chronic pelvic pain conditions.
This study is looking at how certain foods might affect people with chronic pelvic pain, like interstitial cystitis and chronic prostatitis, to find out if changing what you eat can help ease your symptoms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.