Improving treatment for chronic pain in individuals using opioid medications

Adapting Web-based CBT to improve adherence and outcome for individuals with opioid use disorder and chronic pain treated with opioid agonists

NIH-funded research Yale University · NIH-10818411

This study is testing a new online therapy program designed to help people who are dealing with chronic pain while using medications like buprenorphine or methadone, to see if it can improve their treatment compared to regular care.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionYale University NIH-funded
Lab location1 site (New Haven, United States)
Project IDNIH-10818411 on NIH RePORTER

What this research studies

This research aims to enhance the treatment of chronic pain in individuals receiving opioid agonist therapies, such as buprenorphine or methadone. It will develop a web-based cognitive behavioral therapy (CBT) program that integrates coping skills training and support strategies tailored for this population. The project will first pilot test this approach and then conduct a randomized clinical trial to compare its effectiveness against standard care. The goal is to provide a standardized, accessible treatment option that can improve outcomes for those struggling with both chronic pain and opioid use disorder.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals with chronic pain who are currently being treated with opioid agonist therapies.

Not a fit: Patients who do not have chronic pain or are not receiving opioid agonist therapy may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved pain management and better treatment outcomes for individuals with opioid use disorder.

How similar studies have performed: Previous research has shown promise in using web-based cognitive behavioral therapy for various mental health conditions, suggesting potential success for this novel approach.

Where this research is happening

New Haven, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Mental health disorders
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.