Improving treatment for children with perianal Crohn’s disease
Official title: Standardization of Evaluation to Treatment of pediatric perianal Crohn’s disease and improving Outcomes through Networking (SETON)
Funded at University of Michigan at Ann Arbor · NIH-11077870 · Data updated 2026-11-12
This study is looking at how to improve the treatment of kids with perianal Crohn’s disease by finding better ways to manage their care and reduce the use of antibiotics, so that doctors can help them feel better without unnecessary medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $385,669 |
| NIH project number | 5R01HS029313-03 |
| Project ID | NIH-11077870 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with perianal Crohn’s disease who are currently receiving treatment.
✕Less likely to help
Patients without a diagnosis of Crohn’s disease or those who do not have perianal complications may not benefit from this research.
What this research studies
This research investigates how to standardize the treatment of pediatric perianal Crohn’s disease, particularly focusing on reducing unnecessary antibiotic use. By collaborating with multiple pediatric institutions, the study aims to develop a protocol that guides healthcare providers in managing this condition more effectively. The approach includes a multidisciplinary team of specialists who will collect data on current practices and identify barriers to optimal care. The goal is to enhance patient outcomes by minimizing complications associated with antibiotic overuse and improving overall treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better management of pediatric perianal Crohn’s disease, reducing complications and improving quality of life for affected children.
How similar studies have gone: Previous research has shown that standardizing treatment protocols can lead to improved patient outcomes, suggesting that this approach may be effective.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Adler, Jeremy — University of Michigan at Ann Arbor
- Study coordinator: Adler, Jeremy
Related research
Other NIH-funded projects on the same topics.
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Site-specific gene-microbial interactions in children with Crohn’s disease
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-
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A Mayo Clinic team is testing new 3D ultrasound methods to reliably track inflammation and scarring in Crohn’s disease using safe, affordable imaging that could replace more costly scans.
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This project looks at how a specific genetic variation affects how Crohn’s disease works and whether targeting that pathway could lead to new treatments.
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This project uses artificial intelligence plus single-cell and other molecular data to predict which children and teens with Crohn's disease will have mild versus severe or treatment‑resistant disease.
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How IL-23 Blockade in Crohn's Disease Changes Immune Cells
This study looks at how the IL-23 blocking therapy risankizumab affects immune cells in people with Crohn’s disease.
-
Metabolic signatures that predict outcomes in children with Crohn's
This project looks at metabolism patterns in children with Crohn's disease to help predict how their condition will progress and respond to treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.