Improving treatment for children with chronic eye inflammation using methotrexate
Official title: Optimizing methotrexate use for the management of chronic pediatric non-infectious uveitis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11035096 · Data updated 2026-11-12
This study is looking at how to make methotrexate, a common treatment for kids with a serious eye condition called chronic non-infectious uveitis, work better by figuring out which children are most likely to benefit from it, so they can start the right treatment sooner and protect their vision.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $560,861 |
| NIH project number | 5R01EY034565-03 |
| Project ID | NIH-11035096 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with chronic non-infectious uveitis who are beginning treatment with methotrexate.
✕Less likely to help
Patients with other types of uveitis or those who are not starting methotrexate may not benefit from this research.
What this research studies
This research focuses on pediatric chronic non-infectious uveitis, a serious eye condition that can lead to vision loss. It aims to optimize the use of methotrexate, a common treatment, by identifying which children are most likely to respond to it. The study will involve monitoring children starting methotrexate and using advanced imaging and genetic analysis to predict treatment outcomes. By doing so, the researchers hope to initiate more effective therapies sooner and reduce the risk of long-term damage.
Why it matters
Potential benefit: If successful, this research could lead to quicker and more effective treatments for children with chronic eye inflammation, potentially preserving their vision.
How similar studies have gone: Previous research has shown promise in optimizing treatment approaches for chronic inflammatory conditions, suggesting that this study's methods could be effective.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Angeles-Han, Sheila Therese — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Angeles-Han, Sheila Therese
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.