Improving treatment for breast cancer that has spread to the brain
Enhanced Viro-Immunotherapy for Breast Cancer Brain Metastasis
This study is looking at a new way to help breast cancer patients whose cancer has spread to the brain by using a special virus treatment, and it aims to find better ways to boost the immune system's response to this therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10933506 on NIH RePORTER |
What this research studies
This research focuses on enhancing viro-immunotherapy for patients with breast cancer that has metastasized to the brain. It investigates the use of oncolytic herpes simplex virus-1 (oHSV) therapy, which has shown promise in treating other cancers but has limitations in generating a strong immune response in this context. The study aims to understand the mechanisms behind the resistance to this therapy and how to improve its effectiveness by targeting the tumor microenvironment and the immune response. Patients may be involved in trials that explore new treatment combinations to improve outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are breast cancer patients who have developed brain metastasis and are seeking new treatment options.
Not a fit: Patients with early-stage breast cancer or those without brain metastasis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for breast cancer patients with brain metastasis, potentially improving survival rates and quality of life.
How similar studies have performed: Previous research has shown promise with similar viro-immunotherapy approaches in other cancers, indicating potential for success in this novel application.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Yoo, Ji Young — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Yoo, Ji Young
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.