Improving treatment for brain metastasis using immunotherapy
Official title: Optimizing systemic immunotherapy for personalized brain metastasis treatment
Funded at Stanford University · NIH-10925245 · Data updated 2026-11-12
This study is looking at how brain tumors from other cancers impact the immune system and how certain cells can make it harder for the body to fight these tumors, with the goal of finding better treatments that help boost the immune response for patients dealing with brain metastases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 21, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $345,270 |
| NIH project number | 5U54CA261717-04 |
| Project ID | NIH-10925245 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with brain metastases from systemic cancers.
✕Less likely to help
Patients with primary brain tumors or those without brain metastases may not benefit from this research.
What this research studies
This research investigates how brain metastases from systemic cancers affect the immune response and patient survival. It focuses on understanding the role of tumor-associated macrophages (TAMs) in suppressing the immune system's ability to fight these tumors. By studying the mechanisms of immunosuppression and the effects of TGF-β, the research aims to enhance the effectiveness of immunotherapy treatments. Patients may benefit from new strategies that improve their immune response against brain tumors.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapy treatments for patients with brain metastases, potentially improving survival rates.
How similar studies have gone: Previous research has shown promise in using immunotherapy to treat various cancers, suggesting potential success for this novel approach in brain metastasis.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Lim, Michael — Stanford University
- Study coordinator: Lim, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.