Improving treatment for bladder cancer by targeting tumor growth and the immune system
Targeting tumor repopulation and the immune microenvironment to overcome chemoresistance
['FUNDING_R01'] · METHODIST HOSPITAL RESEARCH INSTITUTE · NIH-10900470
This study is looking at ways to improve treatment for muscle invasive bladder cancer by targeting how tumors grow back and how the immune system responds, with the hope of finding better therapies for patients who don’t respond well to chemotherapy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | METHODIST HOSPITAL RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10900470 on ClinicalTrials.gov |
What this research studies
This research focuses on muscle invasive bladder cancer (MIBC), which has a poor response to chemotherapy. The project aims to explore how both tumor repopulation and the immune response can be targeted together to enhance the effectiveness of treatment. By investigating a common pathway that influences both these factors, the researchers hope to develop new adjuvant therapies that can improve patient outcomes. Patients may be involved in trials that test these innovative approaches to overcome chemoresistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with muscle invasive bladder cancer who are facing challenges with current chemotherapy treatments.
Not a fit: Patients with non-muscle invasive bladder cancer or those who have not undergone chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for bladder cancer, improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown promise in targeting tumor repopulation and immune responses, suggesting that this approach could yield significant advancements in treatment.
Where this research is happening
HOUSTON, UNITED STATES
- METHODIST HOSPITAL RESEARCH INSTITUTE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHAN, KEITH SYSON — METHODIST HOSPITAL RESEARCH INSTITUTE
- Study coordinator: CHAN, KEITH SYSON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bladder Cancer