Improving treatment for a childhood hip condition
Immunomodulation of juvenile femoral head osteonecrosis
This study is looking at how the immune system affects hip problems in kids with Legg-Calvé-Perthes disease, and it aims to find new ways to help heal their hips and improve their recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11057523 on NIH RePORTER |
What this research studies
This research focuses on Legg-Calvé-Perthes disease, a serious condition affecting the hip in children aged 2 to 14, which can lead to debilitating osteoarthritis. The study investigates how the immune response, particularly involving macrophages, contributes to the damage in the femoral head due to a lack of blood flow. By using innovative tissue engineering techniques, the researchers aim to transform the harmful inflammatory environment into one that promotes healing and bone regeneration. This approach seeks to address the underlying issues that current treatments do not resolve, potentially leading to better outcomes for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 2 to 14 diagnosed with Legg-Calvé-Perthes disease.
Not a fit: Patients outside the age range of 2 to 14 or those with other unrelated hip conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve healing and reduce the risk of long-term complications for children with Legg-Calvé-Perthes disease.
How similar studies have performed: While the approach of using tissue engineering to address inflammatory responses in bone repair is innovative, similar strategies have shown promise in other areas of regenerative medicine.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Kim, Harry K.w. — Ut Southwestern Medical Center
- Study coordinator: Kim, Harry K.w.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.