Improving treatment decisions for oropharyngeal cancer using advanced imaging techniques
Official title: Precision imaging for risk stratification and personalized therapy of oropharyngeal cancer
Funded at Stanford University · NIH-11058455 · Data updated 2026-11-12
This study is looking to improve how we treat oropharyngeal cancer by using advanced imaging to better understand the disease and figure out the best treatment for each patient, especially for those with HPV-positive and HPV-negative cancers, so that we can minimize side effects and make the treatment more effective.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | July 5, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $604,860 |
| NIH project number | 5R01DE030894-04 |
| Project ID | NIH-11058455 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with oropharyngeal cancer, particularly those with HPV-positive disease.
✕Less likely to help
Patients with other types of cancers or those who do not have oropharyngeal cancer may not benefit from this research.
What this research studies
This research focuses on enhancing the treatment of oropharyngeal cancer (OPC) by using advanced imaging techniques to better understand the disease's progression. It aims to develop new methods for predicting how individual patients will respond to treatment, particularly distinguishing between those with HPV-positive and HPV-negative cancers. By analyzing detailed CT imaging and integrating it with clinical data, the study seeks to create personalized treatment plans that reduce unnecessary toxicity from standard therapies. Patients will be evaluated based on their cancer stage and smoking history to tailor their treatment effectively.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and less toxic treatment options for patients with oropharyngeal cancer.
How similar studies have gone: Previous research has shown promise in using imaging techniques for cancer treatment personalization, indicating that this approach could be effective.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Li, Ruijiang — Stanford University
- Study coordinator: Li, Ruijiang
Related research
Other NIH-funded projects on the same topics.
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AI-powered predictor for chemoradiation response in Veterans with oropharyngeal cancer
A new AI-based tool will help doctors tailor chemoradiation for Veterans with oropharyngeal cancer by predicting how each patient will respond to treatment.
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OPC Survivor: Optimizing Long-Term Health After Oropharyngeal Cancer
This program studies how to improve long-term health and quality of life for adults treated for HPV-related oropharyngeal cancer.
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Optimizing HPV-positive oropharyngeal cancer treatment by selecting patients and reducing therapy intensity
This grant explores whether we can choose the right patients with HPV-positive throat cancer for less intensive, less toxic treatment while maintaining excellent outcomes.
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Biological factors behind different outcomes in HPV+ oropharyngeal cancer
This project looks at why some people with HPV-positive throat cancer have better or worse survival, by studying tumor biology in a large Cleveland patient group.
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Understanding how oral high-risk HPV progresses in people with HIV to prevent oropharyngeal cancer
This study follows HIV patients at high risk for HPV-related throat cancer to understand how oral HPV infections start and change over time, with the goal of catching precancer early.
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Biomarker-based screening to find HPV-related oropharyngeal cancer early
A non-invasive oral gargle test is being developed to detect HPV-related oropharyngeal cancer at early stages, helping people at risk catch cancer sooner.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.