Improving treatment adherence for patients with bipolar disorder and substance use issues after hospital discharge

RCT to Improve Post-Hospital Treatment Adherence for Comorbid Substance Use and Bipolar Disorders

NIH-funded research Butler Hospital (Providence, Ri) · NIH-10456650

This study is looking for ways to help people with both bipolar disorder and substance use issues stick to their treatment after leaving the hospital, using a new support program that includes personal meetings and phone check-ins with family or friends over six months.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionButler Hospital (Providence, Ri) NIH-funded
Lab location1 site (Providence, United States)
Project IDNIH-10456650 on NIH RePORTER

What this research studies

This research focuses on patients who have both bipolar disorder and substance use disorders, aiming to improve their adherence to treatment after they leave the hospital. It involves a novel psychosocial intervention called the Integrated Treatment Adherence Program (ITAP), which combines in-person engagement sessions and follow-up phone calls with support from family or significant others. The program is designed to address the heightened risk of relapse and nonadherence during the critical transition from hospital to outpatient care. By providing tailored support over six months, the research seeks to enhance treatment outcomes for these vulnerable patients.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals diagnosed with both bipolar disorder and substance use disorders who are transitioning from psychiatric hospitalization to outpatient care.

Not a fit: Patients who do not have a diagnosis of bipolar disorder or substance use disorders may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved treatment adherence and better overall health outcomes for patients with comorbid bipolar disorder and substance use disorders.

How similar studies have performed: Previous pilot data on the ITAP intervention have shown promising results, indicating that similar approaches may be effective in improving treatment adherence in this population.

Where this research is happening

Providence, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.