Improving tooth repair with a new dental cement that releases metformin
Targeting the AMPK pathway to enhance dentin repair with novel metformin-releasing dental cements
['FUNDING_R21'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10657804
This study is testing a new dental cement that releases a medication called metformin to help your teeth heal better after injuries or cavities by encouraging your body's natural healing cells to regenerate the hard tissue beneath your enamel, making dental care easier and more affordable for you.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10657804 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the repair of dentin, the hard tissue beneath the enamel of teeth, by using a novel dental cement that releases metformin. The approach aims to stimulate the body's own dental pulp stem cells to regenerate dentin and preserve the vitality of the pulp, especially after injuries or deep cavities. By developing a more affordable and effective bioactive material, the research seeks to provide a better alternative to existing treatments that can be costly and time-consuming. Patients may benefit from less invasive procedures and improved dental health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with damaged or decayed teeth who require dental repair treatments.
Not a fit: Patients with healthy teeth or those who do not require dental interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and affordable treatments for tooth repair, reducing the need for invasive dental procedures.
How similar studies have performed: Previous research has shown promising results in using bioactive materials for dental repair, indicating potential success for this novel approach.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHNEIDER, ABRAHAM — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: SCHNEIDER, ABRAHAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.