Improving tooth eruption in patients with dental disorders
Official title: Pharmacological rescue of tooth eruption disorders
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10887457 · Data updated 2026-11-12
This study is looking at ways to help kids who have trouble with their teeth coming in properly, especially those with genetic conditions or issues from certain medications, by exploring new treatments that can encourage healthy tooth growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $462,810 |
| NIH project number | 5R01DE030416-02 |
| Project ID | NIH-10887457 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and individuals with genetic conditions that cause tooth eruption failure or those affected by bisphosphonate-related dental issues.
✕Less likely to help
Patients with normal tooth eruption and no underlying dental disorders are unlikely to benefit from this research.
What this research studies
This research focuses on addressing disorders that prevent proper tooth eruption, which can significantly affect quality of life. It investigates the role of specific signaling pathways in the dental follicle that regulate tooth eruption, particularly in cases of genetic conditions and bisphosphonate-induced issues in children. The study aims to develop innovative therapies using small molecule inhibitors to enhance signaling pathways that promote tooth eruption. By understanding and manipulating these biological processes, the research seeks to provide effective treatments for patients with severe dental eruption disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore normal tooth eruption, improving patients' ability to chew and overall quality of life.
How similar studies have gone: While the specific approach of using small molecule SIK inhibitors is novel, similar research has shown promise in enhancing signaling pathways for bone and dental health.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Ono, Wanida — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Ono, Wanida
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.