Improving tooth eruption in patients with dental disorders
Pharmacological rescue of tooth eruption disorders
This study is looking at ways to help kids who have trouble with their teeth coming in properly, especially those with genetic conditions or issues from certain medications, by exploring new treatments that can encourage healthy tooth growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10887457 on NIH RePORTER |
What this research studies
This research focuses on addressing disorders that prevent proper tooth eruption, which can significantly affect quality of life. It investigates the role of specific signaling pathways in the dental follicle that regulate tooth eruption, particularly in cases of genetic conditions and bisphosphonate-induced issues in children. The study aims to develop innovative therapies using small molecule inhibitors to enhance signaling pathways that promote tooth eruption. By understanding and manipulating these biological processes, the research seeks to provide effective treatments for patients with severe dental eruption disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and individuals with genetic conditions that cause tooth eruption failure or those affected by bisphosphonate-related dental issues.
Not a fit: Patients with normal tooth eruption and no underlying dental disorders are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore normal tooth eruption, improving patients' ability to chew and overall quality of life.
How similar studies have performed: While the specific approach of using small molecule SIK inhibitors is novel, similar research has shown promise in enhancing signaling pathways for bone and dental health.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Ono, Wanida — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Ono, Wanida
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.