Improving thrombolytic therapy for blood clots
FcRn-enabling strategies for improved thrombolytic therapy
This study is looking at ways to make blood clot treatments work better and last longer in your body, which could help people with serious conditions like pulmonary embolism and stroke feel safer and get better results.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10907686 on NIH RePORTER |
What this research studies
This research focuses on enhancing the effectiveness of thrombolytic therapy, which is used to treat life-threatening blood clots. The approach involves extending the half-life of therapeutic proteins, allowing them to remain active in the bloodstream longer. By attaching these proteins to albumin-binding ligands, the researchers aim to improve their pharmacokinetics and reduce adverse effects. This could lead to safer and more effective treatments for conditions like pulmonary embolism and ischemic stroke.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients experiencing acute thrombotic events, such as pulmonary embolism or ischemic stroke.
Not a fit: Patients with chronic conditions unrelated to thrombotic events may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for patients suffering from acute blood clots.
How similar studies have performed: Previous research has shown promise in extending the half-life of therapeutic proteins, suggesting that this approach could be effective.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Glassman, Patrick Mckenna — Temple Univ of the Commonwealth
- Study coordinator: Glassman, Patrick Mckenna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.