Improving Thinking Speed in Multiple Sclerosis with Online Physical Activity

Internet-Delivered Lifestyle Physical Activity Intervention for Cognitive Processing Speed in Multiple Sclerosis

['FUNDING_R01'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-11128485

This project explores if an online physical activity program can help people with multiple sclerosis improve their thinking speed and overall well-being.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF ILLINOIS AT CHICAGO (nih funded)
Locations1 site (Chicago, UNITED STATES)
Trial IDNIH-11128485 on ClinicalTrials.gov

What this research studies

Many people living with multiple sclerosis (MS) experience slowed thinking speed, which can significantly impact their daily lives, fatigue, mood, and overall quality of life. This project is testing an internet-delivered physical activity program specifically designed to address this challenge. Participants will engage in a structured online program, and researchers will carefully track changes in their cognitive processing speed and other related symptoms. The goal is to determine if this convenient, remote program can lead to immediate and lasting improvements in thinking abilities for those with MS.

Who could benefit from this research

Good fit: Ideal candidates are adults aged 21 or older with multiple sclerosis who experience mild walking difficulties and have slowed cognitive processing speed.

Not a fit: Patients with severe MS-related walking disability or those without objective cognitive processing speed impairment may not receive direct benefit from this specific program.

Why it matters

Potential benefit: If successful, this online program could offer a convenient and accessible way for people with MS to improve their cognitive processing speed, reduce fatigue, lessen anxiety, and enhance their overall quality of life.

How similar studies have performed: A previous pilot study showed promising results, with participants experiencing improved thinking speed and other benefits from a similar online physical activity program.

Where this research is happening

Chicago, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.