Improving the use of real-world data to compare diabetes treatments
Official title: Improving the VAlidity of LInked real-world DAta sTudiEs for Diabetes Mellitus research (VALIDATE-DM)
Funded at Harvard Pilgrim Health Care, INC. · NIH-11024166 · Data updated 2026-11-12
This study is looking to improve how we understand the safety and effectiveness of different diabetes treatments by using real-world health data, so that the results can better reflect the experiences of all patients, not just those in clinical trials.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Pilgrim Health Care, INC. NIH-funded |
| Lab location | 1 site (Canton, UNITED STATES) |
| Project start | March 13, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $828,564 |
| NIH project number | 1R01DK141534-01 |
| Project ID | NIH-11024166 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who are considering or currently using glucose-lowering treatments.
✕Less likely to help
Patients who do not have diabetes or those who are not using glucose-lowering treatments may not benefit from this research.
What this research studies
This research aims to enhance the validity of linked real-world data (RWD) studies that compare the effectiveness and safety of various glucose-lowering treatments for diabetes. By utilizing healthcare claims and electronic health records, the study seeks to address the limitations of traditional randomized controlled trials, which often involve selective populations. The project will focus on linking different RWD sources to provide a more comprehensive understanding of treatment outcomes, ensuring that the findings are robust and applicable to a broader patient population.
Why it matters
Potential benefit: If successful, this research could lead to more informed treatment choices for diabetes patients, improving their health outcomes.
How similar studies have gone: Previous research has shown that using linked real-world data can provide valuable insights into treatment effectiveness, indicating a promising approach for this study.
Where this research is happening
-
Harvard Pilgrim Health Care, INC.
Canton, United States Active
Researchers
- Principal investigator: Toh, Darren — Harvard Pilgrim Health Care, INC.
- Study coordinator: Toh, Darren
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.