Improving the use of real-world data to compare diabetes treatments

Improving the VAlidity of LInked real-world DAta sTudiEs for Diabetes Mellitus research (VALIDATE-DM)

['FUNDING_R01'] · HARVARD PILGRIM HEALTH CARE, INC. · NIH-11024166

This study is looking to improve how we understand the safety and effectiveness of different diabetes treatments by using real-world health data, so that the results can better reflect the experiences of all patients, not just those in clinical trials.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorHARVARD PILGRIM HEALTH CARE, INC. (nih funded)
Locations1 site (Canton, UNITED STATES)
Trial IDNIH-11024166 on ClinicalTrials.gov

What this research studies

This research aims to enhance the validity of linked real-world data (RWD) studies that compare the effectiveness and safety of various glucose-lowering treatments for diabetes. By utilizing healthcare claims and electronic health records, the study seeks to address the limitations of traditional randomized controlled trials, which often involve selective populations. The project will focus on linking different RWD sources to provide a more comprehensive understanding of treatment outcomes, ensuring that the findings are robust and applicable to a broader patient population.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals with diabetes who are considering or currently using glucose-lowering treatments.

Not a fit: Patients who do not have diabetes or those who are not using glucose-lowering treatments may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more informed treatment choices for diabetes patients, improving their health outcomes.

How similar studies have performed: Previous research has shown that using linked real-world data can provide valuable insights into treatment effectiveness, indicating a promising approach for this study.

Where this research is happening

Canton, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.