Improving the use of hydroxyurea for sickle cell disease in Nigeria
Official title: mAnaging siCkle CELl disease through incReased AdopTion of hydroxyurEa in Nigeria (ACCELERATE)
Funded at New York University · NIH-10907044 · Data updated 2026-11-12
This study is working to help more people with sickle cell disease in Nigeria get the medicine hydroxyurea, which can really improve their health and reduce serious problems, by making it easier for doctors to prescribe and manage the treatment.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $671,166 |
| NIH project number | 5U01HL168084-02 |
| Project ID | NIH-10907044 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sickle cell disease living in Nigeria.
✕Less likely to help
Patients with sickle cell disease who are already receiving effective treatment or those living outside Nigeria may not benefit from this research.
What this research studies
This research focuses on increasing the adoption of hydroxyurea (HU) treatment for sickle cell disease (SCD) in Nigeria, where many patients currently lack access to effective care. The project aims to address barriers that prevent healthcare providers from prescribing HU, which has been shown to reduce complications and mortality associated with SCD. By implementing a structured approach that includes screening, treatment initiation, and ongoing management, the research seeks to enhance patient outcomes through better healthcare practices. The study will utilize evidence-based guidelines and algorithms to facilitate the adoption of HU in clinical settings.
Why it matters
Potential benefit: If successful, this research could significantly improve the health and quality of life for patients with sickle cell disease in Nigeria by increasing access to effective treatment.
How similar studies have gone: Previous research has demonstrated success in similar approaches to increasing treatment adoption for sickle cell disease in other regions, indicating potential for positive outcomes in this study.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Peprah, Emmanuel K — New York University
- Study coordinator: Peprah, Emmanuel K
Related research
Other NIH-funded projects on the same topics.
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A computer-driven replica of the spleen is being developed to speed up creating safer and more effective treatments for people with sickle cell disease.
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Accelerating hydroxyurea use for sickle cell disease in Nigeria
A pragmatic study in Nigeria aims to help doctors use hydroxyurea more consistently for people with sickle cell disease.
-
Immune and nerve signals behind acupuncture relief for sickle cell pain
This NIH grant explores how acupuncture helps reduce pain and opioid use for people with sickle cell disease.
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Mindfulness-based Support for Pain and Sleep in Young People with Sickle Cell Disease
A digital mindfulness program is being tailored for adolescents and young adults with sickle cell disease to help with pain and sleep and is being tested for practicality and early effectiveness.
-
How diet affects white blood cells and sickle cell disease
A study looks at how nutrition, from early life to adulthood, influences sickle cell disease by examining neutrophils and disease severity in people with SCD and in a mouse model.
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Nutrition-based plan to ease pain in sickle cell disease
A nutrition-based approach is being tested to reduce pain for people living with sickle cell disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.