Improving the understanding of repetitive DNA in genomes
Dfam: sustainable growth, curation support, and improved quality for mobile element annotation
['FUNDING_OTHER'] · INSTITUTE FOR SYSTEMS BIOLOGY · NIH-10929987
This study is working on creating a better database to help scientists identify and understand repetitive DNA sequences in our genes, which could lead to improved genetic research and better diagnostics for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INSTITUTE FOR SYSTEMS BIOLOGY (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10929987 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the annotation of repetitive DNA, particularly transposable elements, which are significant components of many genomes. By developing a comprehensive database called Dfam, the project aims to provide better tools and methods for recognizing and classifying these repetitive sequences. The approach involves using advanced statistical models and software to improve the accuracy of genome annotations, which can help researchers and clinicians understand genetic variations better. Patients may benefit indirectly through improved genetic research and diagnostics stemming from this enhanced understanding.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with genetic conditions that may involve transposable elements or repetitive DNA sequences.
Not a fit: Patients with conditions unrelated to genetic variations or repetitive DNA may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate genetic analyses and better understanding of genetic disorders linked to repetitive DNA.
How similar studies have performed: Previous research has shown success in improving genome annotation techniques, indicating that this approach has potential for meaningful advancements.
Where this research is happening
SEATTLE, UNITED STATES
- INSTITUTE FOR SYSTEMS BIOLOGY — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUBLEY, ROBERT MACDONALD — INSTITUTE FOR SYSTEMS BIOLOGY
- Study coordinator: HUBLEY, ROBERT MACDONALD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.