Improving the understanding of pancreatic islet function in diabetes
Official title: ADVANCED FUNCTIONAL PHENOTYPING OF PANCREATIC ISLETS USING THE BIOREP PERIFUSION SYSTEM V5
Funded at University of Pennsylvania · NIH-11102705 · Data updated 2026-11-12
This study is looking at how pancreatic islets, which help control insulin and hormone release, respond to different triggers, using a special system to get better insights that could lead to improved diabetes treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 15, 2025 |
| Project end | May 14, 2026 |
| Funding year | 2025 |
| Award (this year) | $93,228 |
| NIH project number | 1S10OD038297-01 |
| Project ID | NIH-11102705 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes or those at risk of developing diabetes.
✕Less likely to help
Patients who do not have diabetes or related endocrine disorders may not receive any benefit from this research.
What this research studies
This research focuses on enhancing the assessment of pancreatic islets, which are crucial for insulin and hormone secretion, using a cutting-edge perifusion system. The study utilizes the Biorep PERI5 system to measure the dynamic release of hormones like insulin and glucagon from isolated islets in response to various stimuli. By providing detailed functional phenotyping, this research aims to improve the understanding of how these cells behave in diabetes, potentially leading to better treatments. Patients may benefit from advancements in diabetes management and therapies derived from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for diabetes patients.
How similar studies have gone: Previous research using similar perifusion techniques has shown promise in understanding pancreatic function, indicating a strong potential for success in this approach.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Stoffers, Doris a — University of Pennsylvania
- Study coordinator: Stoffers, Doris a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.