Improving the understanding of dopamine signaling in diseases.
Official title: Optimizing in vivo dLight recordings for investigating the influence of disease on dopamine signaling.
Funded at University of California at Davis · NIH-11059047 · Data updated 2026-11-12
This study is looking at how a new tool can help us understand dopamine signaling in the brain, which is important for people with neurological and mental health conditions, to find better treatments for those who need them.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | April 1, 2024 |
| Project end | September 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $25,755 |
| NIH project number | 5F31MH135696-02 |
| Project ID | NIH-11059047 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological or neuropsychiatric disorders that involve altered dopamine signaling.
✕Less likely to help
Patients with conditions unrelated to dopamine signaling or those who do not have neurological or neuropsychiatric disorders may not benefit from this research.
What this research studies
This research focuses on using a new optical tool called dLight to study how dopamine signaling is affected in various neurological and neuropsychiatric disorders. By measuring dopamine activity in live models, the researchers aim to uncover differences in dopamine signaling between healthy individuals and those with altered dopamine systems. The findings could lead to better treatments for conditions that currently have limited options. Additionally, the data collected will be shared with the neuroscience community to enhance further research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for neurological and neuropsychiatric disorders related to dopamine signaling.
How similar studies have gone: Other research has shown promise in using optical biosensors for studying neurotransmitter dynamics, indicating that this approach could yield valuable insights.
Where this research is happening
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University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Roshgadol, Jacob — University of California at Davis
- Study coordinator: Roshgadol, Jacob
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.