Improving the survival of transplanted organs by reducing damage from donor mitochondria
Improving transplant organ survival through the mitigation of donor-derived mitochondrial damage-associated molecular patterns
This study is looking at ways to make organ transplants more successful by figuring out how certain molecules released when a donor's brain dies can cause problems like inflammation and rejection, with the goal of improving the quality of organs before they are given to patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10675444 on NIH RePORTER |
What this research studies
This research focuses on enhancing the success of organ transplants by addressing the damage caused by mitochondria from deceased donors. It aims to identify specific molecules released during brain death that contribute to inflammation and rejection of transplanted organs. By understanding these mechanisms, the researchers hope to develop new strategies to improve the quality of organs before they are transplanted. This could lead to better outcomes for patients receiving transplants.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are awaiting organ transplants, particularly those receiving organs from deceased donors.
Not a fit: Patients who are not candidates for organ transplantation or those receiving organs from living donors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly increase the survival rates of transplanted organs and improve patient outcomes.
How similar studies have performed: Other research has shown promise in improving transplant outcomes by targeting inflammation and graft rejection, indicating that this approach could be effective.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Pollara, Justin Joseph — Duke University
- Study coordinator: Pollara, Justin Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.