Improving the survival and function of dopamine neurons for Parkinson's disease treatment
Directing Fate, Subtype Identity and Survival in Human Pluripotent-Derived Midbrain Dopamine Neurons
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11159392
This study is working on finding better ways to create and clean up special brain cells from human stem cells that can help treat Parkinson's disease, with the goal of making sure these cells survive longer after being transplanted into patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11159392 on ClinicalTrials.gov |
What this research studies
This research focuses on developing better methods to generate and purify midbrain dopamine neurons from human stem cells, which are crucial for treating Parkinson's disease. The team aims to enhance the survival rates of these neurons after transplantation, addressing a significant challenge in current therapies. By refining the techniques used to create and isolate these neurons, the research seeks to improve the consistency and effectiveness of cell-based treatments for patients. This work could lead to more reliable outcomes in clinical applications for Parkinson's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who may benefit from advanced cell-based therapies.
Not a fit: Patients with Parkinson's disease who are not candidates for cell-based therapies or those with advanced stages of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cell-based therapies for Parkinson's disease, improving patient outcomes and quality of life.
How similar studies have performed: Previous research has shown promise in using human stem cells for Parkinson's disease treatment, but this approach aims to refine and improve upon existing methods.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STUDER, LORENZ P. — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: STUDER, LORENZ P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.