Improving the success of surgical connections for dialysis access
Official title: SAVE-FistulaS: A Pivotal Study of SelfWrap-Assisted ArterioVEnous FistulaS
Funded at Venostent, INC. · NIH-11082411 · Data updated 2026-11-12
This study is looking for ways to make the connections used for dialysis (called arteriovenous fistulas) work better and last longer for people with kidney failure, so if you join, you might get new treatments that could really help your dialysis experience.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Venostent, INC. NIH-funded |
| Lab location | 1 site (Houston, UNITED STATES) |
| Project start | April 15, 2020 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,212,392 |
| NIH project number | 5R44HL151025-03 |
| Project ID | NIH-11082411 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with chronic kidney disease who require hemodialysis and are undergoing arteriovenous fistula creation.
✕Less likely to help
Patients who are not candidates for hemodialysis or those with conditions that contraindicate AVF creation may not benefit from this research.
What this research studies
This research focuses on enhancing the success rates of arteriovenous fistulas (AVFs), which are crucial for patients undergoing hemodialysis due to kidney failure. The study aims to address the high failure rates of AVFs by investigating a novel approach that helps veins adapt better to the arterial environment, thereby reducing complications and improving blood flow. By utilizing advanced techniques, the research seeks to prevent the common issue of neointimal hyperplasia, which leads to occlusion and loss of function in these surgical connections. Patients participating in this research may receive innovative treatments that could significantly improve their dialysis access.
Why it matters
Potential benefit: If successful, this research could lead to more effective and durable dialysis access for patients with kidney failure, ultimately improving their survival rates.
How similar studies have gone: Previous research has shown promise in improving vascular access techniques, suggesting that innovative approaches like this could lead to significant advancements in patient care.
Where this research is happening
-
Venostent, INC.
Houston, United States Active
Researchers
- Principal investigator: Boire, Timothy C — Venostent, INC.
- Study coordinator: Boire, Timothy C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.