Improving the success of intestinal transplants by reducing early damage to donor organs
Official title: Mitigating Ischemia-Reperfusion Injury to Reduce Early Damage to Intestinal Allografts
Funded at North Carolina State University Raleigh · NIH-11021028 · Data updated 2026-11-12
This study is looking at new ways to keep donor intestines healthy before transplanting them, which could help people with severe intestinal problems have better chances of a successful surgery and a happier life afterward.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $707,388 |
| NIH project number | 5R01AI182590-02 |
| Project ID | NIH-11021028 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and young patients under 11 years old who are facing severe intestinal failure and are potential candidates for intestinal transplantation.
✕Less likely to help
Patients who are not candidates for intestinal transplantation or those with conditions unrelated to intestinal failure may not benefit from this research.
What this research studies
This research focuses on enhancing the success rates of intestinal transplants, which are critical for patients suffering from severe intestinal failure due to conditions like trauma or inflammatory bowel disease. The study aims to mitigate ischemia-reperfusion injury, a significant factor that contributes to transplant failure, by exploring advanced preservation techniques such as normothermic machine perfusion. By improving the viability of donor intestines before transplantation, the research seeks to increase the chances of successful outcomes and improve the quality of life for recipients. Patients may benefit from innovative methods that could lead to better organ preservation and reduced complications post-transplant.
Why it matters
Potential benefit: If successful, this research could significantly improve the success rates of intestinal transplants, leading to better health outcomes for patients with intestinal failure.
How similar studies have gone: Previous research has shown promise in improving transplant outcomes using advanced preservation techniques in other organ types, suggesting potential for success in this novel approach for intestinal transplants.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Gonzalez, Liara M — North Carolina State University Raleigh
- Study coordinator: Gonzalez, Liara M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.