Improving the success of arteriovenous fistulas for dialysis patients
Official title: Manipulating the matrix to improve arteriovenous fistula patency
Funded at Yale University · NIH-10813093 · Data updated 2026-11-12
This study is looking at ways to make arteriovenous fistulas (AVFs) work better for people on hemodialysis by understanding how veins can adapt and improve their function, which could help patients have more successful treatments and fewer surgeries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2019 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $742,551 |
| NIH project number | 5R01HL144476-06 |
| Project ID | NIH-10813093 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with chronic kidney failure who require hemodialysis and are at risk of AVF complications.
✕Less likely to help
Patients who do not require hemodialysis or have alternative vascular access methods may not benefit from this research.
What this research studies
This research investigates how to enhance the effectiveness of arteriovenous fistulas (AVFs), which are crucial for patients undergoing hemodialysis. The study focuses on understanding the biological processes that allow veins to adapt to the conditions of an AVF, aiming to improve their maturation and patency. By using a mouse model, researchers are exploring the role of specific proteins and signaling pathways that influence vein remodeling, which could lead to better outcomes for patients needing dialysis. The goal is to develop novel strategies that can be translated into clinical practice to ensure AVFs remain functional and reduce the need for additional surgical interventions.
Why it matters
Potential benefit: If successful, this research could lead to improved long-term functionality of arteriovenous fistulas, enhancing the quality of life for patients on dialysis.
How similar studies have gone: Previous research has shown promising results in enhancing vascular access through biological interventions, indicating potential for success in this area.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Dardik, Alan — Yale University
- Study coordinator: Dardik, Alan
Related research
Other NIH-funded projects on the same topics.
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Cardiovascular changes after AV fistula creation and how autophagy affects it
A VA-led project looks at how blood vessel remodeling after AV fistula surgery may be helped by understanding and targeting autophagy.
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Nanoparticle delivery to prevent AV fistula narrowing
A new nanoparticle-based approach aims to prevent AV fistula narrowing in people with kidney failure who rely on dialysis.
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Molecular control of arterial-to-vein remodeling in fistula maturation
This study explores how vein cells change to help arteriovenous fistulas mature, with the aim of improving outcomes for people needing hemodialysis.
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How the protein calprotectin affects healing of dialysis fistulas
Looking at whether a protein called calprotectin causes narrowing that keeps new dialysis fistulas from becoming usable for people with kidney failure.
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Improving AV fistula longevity by guiding vein remodeling
A research project is exploring how to help veins adapt better when used for hemodialysis access so patients have fewer costly procedures.
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Bioabsorbable wrap to improve AV fistula outcomes
A new bioabsorbable wrap is being studied to help AV fistula surgery heal better and stay open longer for people needing hemodialysis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.