Improving the success of arteriovenous fistulas for dialysis patients
Manipulating the matrix to improve arteriovenous fistula patency
This study is looking at ways to make arteriovenous fistulas (AVFs) work better for people on hemodialysis by understanding how veins can adapt and improve their function, which could help patients have more successful treatments and fewer surgeries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10813093 on NIH RePORTER |
What this research studies
This research investigates how to enhance the effectiveness of arteriovenous fistulas (AVFs), which are crucial for patients undergoing hemodialysis. The study focuses on understanding the biological processes that allow veins to adapt to the conditions of an AVF, aiming to improve their maturation and patency. By using a mouse model, researchers are exploring the role of specific proteins and signaling pathways that influence vein remodeling, which could lead to better outcomes for patients needing dialysis. The goal is to develop novel strategies that can be translated into clinical practice to ensure AVFs remain functional and reduce the need for additional surgical interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with chronic kidney failure who require hemodialysis and are at risk of AVF complications.
Not a fit: Patients who do not require hemodialysis or have alternative vascular access methods may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved long-term functionality of arteriovenous fistulas, enhancing the quality of life for patients on dialysis.
How similar studies have performed: Previous research has shown promising results in enhancing vascular access through biological interventions, indicating potential for success in this area.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Dardik, Alan — Yale University
- Study coordinator: Dardik, Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.