Improving the study of small proteins using advanced imaging techniques
Breaking barriers in CryoEM through computational protein design
This study is working on improving a special imaging technique to help scientists see tiny proteins better, which could lead to new treatments for diseases related to these proteins, especially those that affect how our bodies respond to signals.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10873958 on NIH RePORTER |
What this research studies
This research focuses on enhancing the capabilities of cryogenic electron microscopy (cryoEM) to study small proteins and their complexes, which are crucial for understanding various human diseases. By utilizing computational protein design, the team aims to overcome the limitations of cryoEM that currently prevent effective imaging of proteins smaller than 40 kDa. The approach involves designing proteins to improve their visibility in cryoEM, allowing for high-resolution observation of their structures and functions in native states. This could lead to significant advancements in drug development, particularly for conditions involving G protein-coupled receptors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to small proteins, such as certain cancers or cardiac arrhythmias.
Not a fit: Patients with conditions not involving small proteins or those unrelated to the mechanisms studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in drug development for diseases linked to small proteins, improving treatment options for patients.
How similar studies have performed: Other research has shown promise in enhancing imaging techniques for proteins, but this specific approach using computational design for small proteins is relatively novel.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Gonen, Shane — University of California-Irvine
- Study coordinator: Gonen, Shane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.