NIH-funded research R01 grant

Improving the speed and quality of dental zirconia production

Official title: Ultrafast sintering of dental zirconia: composition-processing-property relationships with high-throughput fail-fast screening

Funded at University of Pennsylvania · NIH-10922819 · Data updated 2026-11-12

This study is working on a faster way to make dental crowns and bridges using a special material called zirconia, so that dentists can create strong and beautiful restorations for you in just about a minute instead of hours.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Pennsylvania
NIH-funded
Lab location1 site (Philadelphia, United States)
Project startSeptember 6, 2023
Project endAugust 31, 2028
Funding year2024
Award (this year)$449,557
NIH project number5R01DE033545-02
Project IDNIH-10922819 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are patients requiring dental restorations, such as crowns or prosthetics, who are seeking quicker treatment options.

Less likely to help

Patients who do not require dental restorations or those with conditions that contraindicate the use of zirconia materials may not benefit from this research.

What this research studies

This research focuses on enhancing the production process of dental zirconia, a material used for dental restorations, by drastically reducing the time it takes to sinter the material while maintaining its strength and translucency. The approach involves developing novel ultrafast sintering technologies that can achieve sintering in about 60 seconds, compared to traditional methods that take several hours. By optimizing the composition and processing conditions, the research aims to improve the quality of dental prosthetics, making them more accessible for chairside applications in dental practices.

Why it matters

Potential benefit: If successful, this research could lead to faster and higher-quality dental restorations, improving patient outcomes and reducing the time spent in dental chairs.

How similar studies have gone: While there have been advancements in dental material processing, this ultrafast sintering approach is relatively novel and has not been extensively tested in clinical settings.

Where this research is happening

  • University of Pennsylvania
    Philadelphia, United States
    Active

Researchers

  • Principal investigator: Zhang, Yu — University of Pennsylvania
  • Study coordinator: Zhang, Yu

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.