Improving the safety and performance of brain stimulation electrodes
Development and In Vivo Validation of a Theoretical Framework and Practical Methods to Improve Safety and Efficacy of Neuromodulation Electrodes
This project develops better testing methods and practical designs to make implanted brain‑stimulation electrodes safer and more effective for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10809769 on NIH RePORTER |
What this research studies
This project aims to build a clearer safety framework for implanted electrical electrodes by combining improved benchtop tests with real‑world in‑vivo validation. Researchers will refine testing methods to better predict long‑term problems like corrosion and tissue damage, and adapt those methods for coated, thin‑film, and high‑density microelectrodes. The team will also test how different pulse shapes and stimulation patterns affect safety and durability. Results and methods will be shared so device makers and regulators can use them to design safer implants.
Who could benefit from this research
Good fit: Ideal candidates are people who currently have or may receive implanted neuromodulation devices (for example deep brain stimulation, spinal cord stimulation, cochlear implants, or vagus nerve stimulators).
Not a fit: People without conditions treated by electrical implants or those pursuing only non‑electrical treatments are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, the work could reduce complications, extend implant lifespan, and enable safer next‑generation neuromodulation therapies.
How similar studies have performed: Existing FDA‑focused benchtop tests are largely based on older empirical limits, so while some benchtop methods exist this project’s combined theoretical and in‑vivo validation approach is relatively novel.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Ludwig, Kip a — University of Wisconsin-Madison
- Study coordinator: Ludwig, Kip a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.