Improving the safety and effectiveness of opioids for children and nursing mothers during surgery
Perioperative Precision Medicine: Translating Science to Clinical Practice to Improve Safety and Efficacy of Opioids in Neonates, Children and Nursing Mothers
This study is looking to improve pain relief for babies, kids, and nursing moms after surgery by using genetic testing to tailor opioid use, helping to ensure they get the right amount of medicine while reducing the risk of side effects and misuse.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10828901 on NIH RePORTER |
What this research studies
This research focuses on enhancing pain management for neonates, children, and nursing mothers undergoing surgery by addressing the risks associated with opioid use. It aims to implement a personalized approach to opioid administration based on genetic testing, which can help predict how individuals metabolize these medications. By identifying genetic variations that affect opioid metabolism, the study seeks to optimize pain control while minimizing adverse effects such as respiratory depression and long-term misuse. The research will develop a framework for integrating this precision medicine approach into clinical practice.
Who could benefit from this research
Good fit: Ideal candidates for this research include neonates, children undergoing surgery, and nursing mothers who require pain management.
Not a fit: Patients who are not undergoing surgery or who do not require opioid pain management may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective pain management strategies for vulnerable populations, reducing the risk of opioid-related complications.
How similar studies have performed: Previous research has shown promise in using genetic testing to personalize opioid therapy, indicating that this approach could be effective in improving patient outcomes.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Sadhasivam, Senthilkumar — University of Pittsburgh at Pittsburgh
- Study coordinator: Sadhasivam, Senthilkumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.