Improving the production of heart cells from stem cells
Official title: Technologies enabling robust closed-loop manufacturing of human pluripotent stem cell-derived cardiomyocytes
Funded at University of Wisconsin-Madison · NIH-11073366 · Data updated 2026-11-12
This study is working on making heart cells from stem cells better and more reliable, so that patients with heart disease can receive more effective treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | February 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $590,283 |
| NIH project number | 1R01HL178095-01 |
| Project ID | NIH-11073366 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from heart disease or conditions that could benefit from heart cell therapies.
✕Less likely to help
Patients with conditions unrelated to heart disease or those not requiring stem cell therapies may not benefit from this research.
What this research studies
This research focuses on enhancing the manufacturing process of heart cells derived from human pluripotent stem cells. By developing advanced feedback-controlled systems, the project aims to reduce variability and improve the quality of these cells, which are crucial for therapies targeting heart disease and other conditions. The approach involves analyzing genetic and epigenetic factors that influence cell differentiation, particularly in transitioning from 2D to 3D cell cultures. Patients may benefit from more consistent and effective stem cell therapies as a result of this improved manufacturing process.
Why it matters
Potential benefit: If successful, this research could lead to more reliable and effective heart cell therapies for patients with heart disease.
How similar studies have gone: Other research has shown promise in improving stem cell differentiation processes, indicating potential for success in this novel approach.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Palecek, Sean P — University of Wisconsin-Madison
- Study coordinator: Palecek, Sean P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.