Improving the process of hydrogenating organic compounds for drug development
Official title: Heterogeneous Directed Hydrogenation of Arenes and Olefins with Chemo- and Stereoselectivity
Funded at Purdue University · NIH-11087666 · Data updated 2026-11-12
This study is exploring new ways to make important ingredients for medicines by using special materials that help create better and more effective drugs, which could mean better treatments for patients with fewer side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $373,072 |
| NIH project number | 5R35GM151120-03 |
| Project ID | NIH-11087666 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research are individuals who may require new or improved medications for various health conditions.
✕Less likely to help
Patients who are not seeking new drug therapies or those with conditions that do not require pharmaceutical intervention may not benefit from this research.
What this research studies
This research focuses on enhancing the hydrogenation process of unsaturated organic compounds, which is crucial for developing new pharmaceuticals. By using innovative bimetallic alloy catalysts, the project aims to achieve better selectivity and stereochemistry in these reactions. The approach involves directing the reactivity of the catalysts to improve the structural diversity of drug-like compounds, potentially leading to more effective medications. Patients may benefit from this research as it could lead to the development of new drugs with improved efficacy and fewer side effects.
Why it matters
Potential benefit: If successful, this research could lead to the creation of more effective and diverse pharmaceutical compounds.
How similar studies have gone: Previous research has shown promise in using directed reactivity with bimetallic catalysts, indicating potential for success in this novel approach.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Li, Christina W — Purdue University
- Study coordinator: Li, Christina W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.