Improving the process of determining protein sequences using fluorescent labeling
Official title: Facilitating the Chemistry of Fluorosequencing
Funded at University of Texas at Austin · NIH-11042715 · Data updated 2026-11-12
This study is testing a new way to look at proteins using special glowing markers, which could help scientists better understand and identify proteins in health and medical tests.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project start | May 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $345,979 |
| NIH project number | 5R35GM149308-03 |
| Project ID | NIH-11042715 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that require precise protein analysis, such as certain genetic disorders or cancers.
✕Less likely to help
Patients with conditions that do not involve protein sequencing or those who are not undergoing diagnostic evaluations may not benefit from this research.
What this research studies
This research focuses on developing a new technique called fluorosequencing to enhance the analysis of protein sequences. By labeling amino acids with fluorescent markers and using advanced microscopy, the researchers aim to identify and sequence proteins one molecule at a time. This method allows for the analysis of complex mixtures of peptides in parallel, which could lead to more efficient and accurate protein sequencing. The research seeks to overcome current limitations in protein analysis methods, making it more accessible for various applications in health and diagnostics.
Why it matters
Potential benefit: If successful, this research could significantly improve the accuracy and efficiency of protein sequencing, leading to better diagnostic tools and treatments for various diseases.
How similar studies have gone: While the approach of using fluorescent labeling for protein sequencing is innovative, similar techniques have shown promise in other areas of genomics and diagnostics.
Where this research is happening
-
University of Texas at Austin
Austin, United States Active
Researchers
- Principal investigator: Anslyn, Eric V. — University of Texas at Austin
- Study coordinator: Anslyn, Eric V.
Related research
Other NIH-funded projects on the same topics.
-
Translating new nerve grafts to clinical use
Aims to bring advanced nerve graft technology that uses PEG-fusion and localized immunosuppression to patients with nerve gaps.
-
GABA-A receptor gating mechanisms and how drugs affect them
Researchers are studying how GABA-A receptor gates work and how medicines can modulate them to help people with epilepsy, Alzheimer's-related symptoms, and other brain disorders.
-
Nanoparticles that calm inflammation after artery procedures
A new nanoparticle inspired by dying cells is being tested to reduce inflammation after artery procedures and help PAD patients heal better.
-
Silent speech interface using a wearable tongue tracker to help people after laryngectomy communicate
A wearable system with tongue sensors and intraoral components aims to let people without a vocal cord use natural-sounding speech in daily life.
-
Understanding and reversing abnormal brain activity in Alzheimer's disease
Aims to understand how unusual brain activity contributes to Alzheimer’s and test ways to reverse it to help people with the condition.
-
CFDE Cloud Workspace to help researchers share and analyze data
A cloud-based workspace will let a wide range of researchers import, integrate, and analyze data from CFDE and other sources using familiar tools and workflows.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.