Improving the preservation of kidney transplants using advanced cryoprotectants
Official title: Greatly Extended Subzero Ischemic Storage of Renal Allografts Using Novel Bio-inspired Next Generation Cryoprotectants
Funded at X-Therma INC. · NIH-10895527 · Data updated 2026-11-12
This study is looking at new ways to keep kidney transplants safe and healthy for longer periods, which could help more people get the organs they need and recover faster after surgery.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | X-Therma INC. NIH-funded |
| Lab location | 1 site (Hercules, UNITED STATES) |
| Project start | August 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,015,699 |
| NIH project number | 5R44DK136396-02 |
| Project ID | NIH-10895527 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals awaiting kidney transplants, particularly those in need of improved organ preservation methods.
✕Less likely to help
Patients who have already received a kidney transplant or those not in need of a transplant may not benefit from this research.
What this research studies
This research focuses on enhancing the preservation of kidney transplants by using innovative cryoprotectants that allow for extended storage times without freezing. By preventing ischemic damage during the procurement of kidneys, the study aims to improve graft viability, leading to quicker patient recovery and reduced hospital stays. The approach involves pre-clinical testing of these cryoprotectants on porcine kidneys, with the goal of extending the cold ischemia time up to 120 hours. This could significantly change how kidney transplants are managed and increase the availability of organs for patients in need.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes for kidney transplant patients, including faster recovery times and reduced healthcare costs.
How similar studies have gone: Other research has shown promise in organ preservation techniques, but this specific approach using novel cryoprotectants is relatively new and untested in clinical settings.
Where this research is happening
-
X-Therma INC.
Hercules, United States Active
Researchers
- Principal investigator: Kline, Mark a — X-Therma INC.
- Study coordinator: Kline, Mark a
Related research
Other NIH-funded projects on the same topics.
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Extended, non-frozen storage for kidney transplants using smart cryoprotectants
A new approach uses advanced cryoprotectants to dramatically extend the time kidneys can be kept before transplant, aiming to save more lives by reducing geographic barriers.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.