Improving the persistence of immune cells that target HIV
Official title: ENHANCEMENT OF CD4CAR T-CELL PERSISTENCE IN VIVO
Funded at University of Washington · NIH-10921058 · Data updated 2026-11-12
This study is looking at ways to make special immune cells called CD4CAR T cells work better for people with HIV by helping them stay in the body longer, so they can help control the virus without needing constant medication.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 5, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $186,408 |
| NIH project number | 1K08AI183990-01 |
| Project ID | NIH-10921058 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who may benefit from innovative therapies targeting the virus.
✕Less likely to help
Patients who are not living with HIV or those who have advanced stages of the disease with limited treatment options may not benefit from this research.
What this research studies
This research focuses on enhancing the effectiveness of CD4CAR T cells, a type of immune cell engineered to target HIV. The study aims to understand how these cells can persist longer in the body, which is crucial for controlling the virus without continuous medication. By using a non-human primate model, researchers are investigating the challenges posed by the presence of the virus in the bloodstream and how to overcome these obstacles to improve treatment outcomes for people living with HIV.
Why it matters
Potential benefit: If successful, this research could lead to more effective long-term treatments for HIV, potentially reducing the need for lifelong antiretroviral therapy.
How similar studies have gone: Previous research has shown promise in using CAR T cell therapies for cancer, but this approach for HIV is still being explored and is considered novel.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Bui, John K — University of Washington
- Study coordinator: Bui, John K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.