Improving the performance of engineered blood vessels for heart surgery
Improving Tissue Engineered Vascular Graft Performance via Computational Modeling
This study is looking at ways to make better blood vessel grafts for kids with heart problems, using special computer models and tests on young sheep, so that these grafts work well and help patients heal more effectively after surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-11066539 on NIH RePORTER |
What this research studies
This research focuses on enhancing tissue engineered vascular grafts (TEVGs) to improve their effectiveness in cardiovascular care, particularly for congenital heart surgery. By utilizing a combination of computational modeling and experimental data from juvenile sheep, the team aims to optimize the design of these grafts to ensure better integration and function within the body. The study will analyze how these grafts develop over time and adapt to the body's natural processes, ultimately leading to improved patient outcomes. Patients may benefit from more effective and reliable vascular grafts that can be used in surgical procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adults undergoing procedures involving tissue engineered vascular grafts, particularly those with congenital heart conditions.
Not a fit: Patients who do not require vascular grafts or those with conditions unrelated to cardiovascular surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vascular grafts that improve surgical outcomes for patients with congenital heart defects.
How similar studies have performed: Previous research has shown promise in the development of tissue engineered vascular grafts, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Breuer, Christopher Kane — Research Inst Nationwide Children's Hosp
- Study coordinator: Breuer, Christopher Kane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.