Improving the measurement and staging of lymphoma using advanced imaging techniques
Official title: Models and methods for automatically measuring disease body-wide and staging disease via FDG-PET/CT in Lymphoma
Funded at University of Pennsylvania · NIH-10893984 · Data updated 2026-11-12
This study is working on new ways to use advanced imaging techniques to help doctors better diagnose and monitor diffuse large B-cell lymphoma (DLBCL), so that patients like you can receive more accurate treatment plans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 12, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $545,026 |
| NIH project number | 5R01CA255748-04 |
| Project ID | NIH-10893984 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with diffuse large B-cell lymphoma (DLBCL) who are 21 years or older.
✕Less likely to help
Patients with other types of lymphoma or those under 21 years old may not receive direct benefits from this research.
What this research studies
This research focuses on enhancing the ability to diagnose and monitor diffuse large B-cell lymphoma (DLBCL) through advanced imaging techniques like FDG-PET/CT. It aims to develop automated methods for accurately identifying and analyzing anatomical structures and disease areas in medical images, which is crucial for effective treatment planning. By creating a comprehensive approach to image segmentation that works across the entire body, the research seeks to provide more precise disease quantification and staging. Patients with DLBCL will be the primary focus, benefiting from improved diagnostic accuracy and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnosis and monitoring of lymphoma, ultimately improving treatment outcomes for patients.
How similar studies have gone: Previous research in quantitative radiology has shown promise in improving diagnostic techniques, suggesting that this approach could yield significant advancements in lymphoma treatment.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Udupa, Jayaram K — University of Pennsylvania
- Study coordinator: Udupa, Jayaram K
Related research
Other NIH-funded projects on the same topics.
-
Understanding why Black and Hispanic Hodgkin lymphoma patients have worse survival
A patient-centered study to uncover social and care factors that contribute to lower survival among Black and Hispanic people with Hodgkin lymphoma across all ages.
-
Adding PSMA PET/CT imaging to liver cancer care for veterans
This project tests a new PET imaging approach to help diagnose and guide treatment for liver cancer in veterans.
-
Preventing follicular lymphoma progression with precision therapy
This grant tests a targeted approach to stop follicular lymphoma from getting worse or turning into a more aggressive cancer.
-
Novel combination therapy for non-Hodgkin lymphoma in people and dogs
A new treatment combo using an oncolytic virus and other therapies is being tested to help people with hard-to-treat non-Hodgkin lymphoma, with studies also involving dogs to better understand responses.
-
Cyclin D1 and DNA Repair in Mantle Cell Lymphoma: A Path to New Therapies
A clinician-researcher at Mayo Clinic is pursuing advanced training and research to understand how Cyclin D1 drives replication stress and to explore new targeted treatments for high-risk mantle cell lymphoma.
-
New ways to cut radiation and time in kids’ PET/CT scans
A project to dramatically reduce radiation dose and scan time for pediatric PET/CT imaging using new deep learning tools so children diagnosed with cancer (and other conditions) can stay safe during imaging.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.