Improving the manufacturing process of monoclonal antibodies
Advancing continuous biomanufacturing of monoclonal antibodies using an experimentally validated modeling platform
This study is working on making the production of important medicines called monoclonal antibodies faster and more reliable, so patients can get the treatments they need more easily.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10907532 on NIH RePORTER |
What this research studies
This research focuses on enhancing the continuous manufacturing of monoclonal antibodies (mAbs) by developing a sophisticated modeling platform that integrates experimental data with computational methods. The project aims to optimize both the upstream cell culture and downstream purification processes, ensuring that the production of mAbs meets increasing demand. By validating the models with experimental evidence, the research seeks to improve the understanding of critical quality attributes and optimize operating conditions for better product quality. Patients may benefit from more efficient and reliable production of therapeutic antibodies that are crucial for treating various conditions.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include patients requiring monoclonal antibody therapies for conditions such as cancer, autoimmune diseases, and other serious health issues.
Not a fit: Patients who do not require monoclonal antibody treatments or those with conditions not addressed by these therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more efficient production of monoclonal antibodies, resulting in better availability of these important therapies for patients.
How similar studies have performed: Other research in the field of biomanufacturing has shown success in optimizing production processes, indicating that this approach has potential for significant advancements.
Where this research is happening
Newark, UNITED STATES
- University of Delaware — Newark, United States (Active)
Researchers
- Principal investigator: Ierapetritou, Marianthi — University of Delaware
- Study coordinator: Ierapetritou, Marianthi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.