Improving the integration of transplanted photoreceptors in the retina
Official title: Restoring cytoskeletal dynamics to improve circuit integration of transplanted photoreceptors
Funded at University of Wisconsin-Madison · NIH-10996160 · Data updated 2026-11-12
This study is looking at ways to make cell replacement treatments for age-related macular degeneration (AMD) work better by helping new light-sensing cells connect properly in the eye, so people with AMD can see better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $187,715 |
| NIH project number | 5R21EY035831-02 |
| Project ID | NIH-10996160 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing age-related macular degeneration.
✕Less likely to help
Patients with other forms of retinal diseases not related to age or those who are not suitable for cell transplantation may not benefit from this research.
What this research studies
This research focuses on enhancing the success of cell replacement therapies for age-related macular degeneration (AMD) by improving the integration of transplanted photoreceptors into existing retinal circuits. The approach involves genetically modifying photoreceptors to enhance their ability to extend processes and form synapses, which are crucial for proper function. By understanding the age-dependent changes that affect the motility of these cells, the researchers aim to identify targets that can improve their integration and functionality after transplantation.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with age-related macular degeneration, potentially restoring vision.
How similar studies have gone: Previous research has shown promise in cell replacement therapies for retinal diseases, indicating that this approach could be a significant advancement in treatment.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Gomez, Timothy M — University of Wisconsin-Madison
- Study coordinator: Gomez, Timothy M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.