Improving the integration of allografts for ACL repair using collagen technology
Official title: AlloBrace: Pure Collagen Augment to Improve Performance and Integration of Allografts
Funded at Collamedix INC. · NIH-10919715 · Data updated 2026-11-12
This study is testing a new product called AlloBrace that uses special collagen to help improve the healing of tissue grafts used in ACL surgeries, aiming to give patients with ACL tears a better chance at a successful recovery.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Collamedix INC. NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $300,000 |
| NIH project number | 1R43AR083784-01A1 |
| Project ID | NIH-10919715 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an ACL tear and are considering surgical reconstruction using an allograft.
✕Less likely to help
Patients who have not suffered an ACL injury or those who are not candidates for ACL reconstruction surgery may not benefit from this research.
What this research studies
This research focuses on enhancing the performance and integration of allografts used in anterior cruciate ligament (ACL) reconstruction. It aims to develop a product called AlloBrace, which utilizes high-strength pure-collagen to improve the biological integration of soft tissue allografts. By stimulating ligamentization and promoting true bony growth at the interface, the research seeks to reduce the failure rates associated with allografts. Patients who have suffered ACL tears may benefit from this innovative approach, which could lead to better surgical outcomes and recovery.
Why it matters
Potential benefit: If successful, this research could significantly lower the failure rates of allografts in ACL surgeries, leading to improved knee stability and mobility for patients.
How similar studies have gone: Previous research has shown promise in improving graft integration techniques, but the specific approach using AlloBrace is novel and untested.
Where this research is happening
-
Collamedix INC.
Cleveland, United States Active
Researchers
- Principal investigator: Shankar, Subba — Collamedix INC.
- Study coordinator: Shankar, Subba
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.