Improving the healing of tendon injuries
Modulating Cell-fate to Promote Regenerative Tendon Healing
This study is looking at special cells that help tendons heal and how they work with other cells, hoping to find better ways to treat tendon injuries and improve healing for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11086052 on NIH RePORTER |
What this research studies
This research investigates how specific cells involved in tendon healing, known as myofibroblasts, contribute to the healing process and the formation of scar tissue. By examining different types of myofibroblasts and their interactions with other cells, such as macrophages, the research aims to understand how to promote better healing outcomes. The approach includes studying the molecular profiles of these cells and their lineage to identify potential therapeutic targets. Patients may benefit from insights that could lead to improved treatments for tendon injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with tendon injuries who are experiencing delayed or problematic healing.
Not a fit: Patients with tendon injuries that have already healed properly or those with chronic conditions unrelated to tendon healing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies that enhance tendon healing and reduce scar tissue formation.
How similar studies have performed: Other research has shown promising results in understanding myofibroblast dynamics in tissue healing, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Loiselle, Alayna — University of Rochester
- Study coordinator: Loiselle, Alayna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.