Improving the function of vascular grafts using nitric oxide
Official title: Enhanced Prosthetic Vascular Graft Function by Local Release of Nitric Oxide
Funded at Nytricx INC. · NIH-11005472 · Data updated 2026-11-12
This study is looking at a new type of blood vessel graft that releases a helpful gas called nitric oxide to reduce problems like infections and blood clots, making it safer and more effective for patients needing artery repairs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nytricx INC. NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $311,824 |
| NIH project number | 1R41HL176245-01 |
| Project ID | NIH-11005472 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be patients requiring endovascular arterial repair who are at risk for complications associated with current graft technologies.
✕Less likely to help
Patients who do not require vascular grafts or those with contraindications to nitric oxide therapies may not benefit from this research.
What this research studies
This research focuses on enhancing the performance of vascular grafts used in endovascular arterial repair by integrating nitric oxide-releasing technologies. The approach aims to address common complications such as infection, neointimal proliferation, and thrombosis that can lead to device failure and increased cardiac risks. By creating a biocompatible interface that releases nitric oxide, the research seeks to improve patient outcomes by preventing these complications. The methodology involves the development of a new type of graft that can be tested in preclinical models before potential clinical application.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective vascular grafts, reducing complications and improving recovery for patients undergoing arterial repair.
How similar studies have gone: Previous research has shown promise in using nitric oxide-releasing technologies in medical devices, indicating potential for success in this novel application.
Where this research is happening
-
Nytricx INC.
Athens, United States Active
Researchers
- Principal investigator: Shebuski, Ronald J. — Nytricx INC.
- Study coordinator: Shebuski, Ronald J.
Related research
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New catheters that release Nitric Oxide to prevent infections and blood clots
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New catheters that release nitric oxide to prevent infections and blood clots
This study is testing a new type of catheter that releases a natural substance to help prevent infections and blood clots, which could make life easier and safer for patients who need catheters for a long time.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.