Improving the function of vascular grafts using nitric oxide
Enhanced Prosthetic Vascular Graft Function by Local Release of Nitric Oxide
['FUNDING_OTHER'] · NYTRICX INC. · NIH-11005472
This study is looking at a new type of blood vessel graft that releases a helpful gas called nitric oxide to reduce problems like infections and blood clots, making it safer and more effective for patients needing artery repairs.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NYTRICX INC. (nih funded) |
| Locations | 1 site (ATHENS, UNITED STATES) |
| Trial ID | NIH-11005472 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the performance of vascular grafts used in endovascular arterial repair by integrating nitric oxide-releasing technologies. The approach aims to address common complications such as infection, neointimal proliferation, and thrombosis that can lead to device failure and increased cardiac risks. By creating a biocompatible interface that releases nitric oxide, the research seeks to improve patient outcomes by preventing these complications. The methodology involves the development of a new type of graft that can be tested in preclinical models before potential clinical application.
Who could benefit from this research
Good fit: Ideal candidates for this research would be patients requiring endovascular arterial repair who are at risk for complications associated with current graft technologies.
Not a fit: Patients who do not require vascular grafts or those with contraindications to nitric oxide therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective vascular grafts, reducing complications and improving recovery for patients undergoing arterial repair.
How similar studies have performed: Previous research has shown promise in using nitric oxide-releasing technologies in medical devices, indicating potential for success in this novel application.
Where this research is happening
ATHENS, UNITED STATES
- NYTRICX INC. — ATHENS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHEBUSKI, RONALD J. — NYTRICX INC.
- Study coordinator: SHEBUSKI, RONALD J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.