Improving the function of blood stem cells for better transplantation outcomes
Official title: Omics interrogation of functionally competent hematopoieitic stem cells
Funded at Indiana University Indianapolis · NIH-11223486 · Data updated 2026-11-12
This study is looking at how using umbilical cord blood can make blood stem cell transplants better, which could help patients with blood disorders have more successful treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $248,677 |
| NIH project number | 4R00HL166790-02 |
| Project ID | NIH-11223486 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with blood disorders requiring hematopoietic stem cell transplantation, including both malignant and non-malignant conditions.
✕Less likely to help
Patients with conditions that do not involve hematopoietic stem cell transplantation or those who are not candidates for such procedures may not benefit from this research.
What this research studies
This research focuses on enhancing the effectiveness of hematopoietic stem cell transplantation (HCT) by investigating umbilical cord blood as a source of these cells. The study aims to increase the number and functional competency of hematopoietic stem cells, which are crucial for treating various blood disorders. By utilizing advanced techniques in omics, cell biology, and biochemistry, the research seeks to identify new therapeutic strategies that can improve patient outcomes in HCT. Patients may benefit from improved treatments that enhance the success rates of blood stem cell transplants.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients undergoing blood stem cell transplantation, potentially improving their recovery and survival rates.
How similar studies have gone: Previous research has shown promise in enhancing hematopoietic stem cell function using similar approaches, indicating potential for success in this area.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Ropa, James Patrick — Indiana University Indianapolis
- Study coordinator: Ropa, James Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.