Improving the function of arteriovenous fistulas for dialysis patients
Official title: Development of a Treatment to Improve Arteriovenous Fistula Function
Funded at Pavaj Vascular Corporation · NIH-10919089 · Data updated 2026-11-12
This study is testing a new treatment to help improve the function of arteriovenous fistulas (AVFs) for people on hemodialysis, aiming to prevent problems that can cause these important access points to fail.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pavaj Vascular Corporation NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 18, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $499,890 |
| NIH project number | 1R44DK139817-01 |
| Project ID | NIH-10919089 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with end-stage kidney disease who require hemodialysis and have arteriovenous fistulas.
✕Less likely to help
Patients who do not require hemodialysis or have alternative vascular access methods may not benefit from this research.
What this research studies
This research focuses on developing a new treatment to enhance the function of arteriovenous fistulas (AVFs), which are crucial for patients undergoing hemodialysis. The study aims to address the common issue of venous stenosis, a condition that leads to AVF failure and affects many patients with end-stage kidney disease. By utilizing a novel therapy that targets the biological mechanisms behind venous stenosis, the research seeks to improve the longevity and effectiveness of AVFs, ultimately benefiting patients who rely on these for dialysis. The approach involves the use of nanoparticles to deliver therapeutic agents directly to the site of the AVF, potentially offering a non-invasive solution to a significant problem in dialysis care.
Why it matters
Potential benefit: If successful, this research could significantly improve the longevity and functionality of arteriovenous fistulas, enhancing the quality of life for patients requiring hemodialysis.
How similar studies have gone: Other research has shown promise in using targeted therapies to improve vascular access outcomes, suggesting that this approach could be effective.
Where this research is happening
-
Pavaj Vascular Corporation
Rochester, United States Active
Researchers
- Principal investigator: Miller, Aaron — Pavaj Vascular Corporation
- Study coordinator: Miller, Aaron
Related research
Other NIH-funded projects on the same topics.
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Cardiovascular changes after AV fistula creation and how autophagy affects it
A VA-led project looks at how blood vessel remodeling after AV fistula surgery may be helped by understanding and targeting autophagy.
-
Nanoparticle delivery to prevent AV fistula narrowing
A new nanoparticle-based approach aims to prevent AV fistula narrowing in people with kidney failure who rely on dialysis.
-
Molecular control of arterial-to-vein remodeling in fistula maturation
This study explores how vein cells change to help arteriovenous fistulas mature, with the aim of improving outcomes for people needing hemodialysis.
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How the protein calprotectin affects healing of dialysis fistulas
Looking at whether a protein called calprotectin causes narrowing that keeps new dialysis fistulas from becoming usable for people with kidney failure.
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Improving AV fistula longevity by guiding vein remodeling
A research project is exploring how to help veins adapt better when used for hemodialysis access so patients have fewer costly procedures.
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Bioabsorbable wrap to improve AV fistula outcomes
A new bioabsorbable wrap is being studied to help AV fistula surgery heal better and stay open longer for people needing hemodialysis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.