Improving the extraction of genetic material from preserved tissue samples
Official title: Improving extraction success of FFPE samples with automated and reliable microfluidic sample preparation
Funded at Redbud Labs, INC. · NIH-10931835 · Data updated 2026-11-12
This study is working on a new, easier way to get DNA and RNA from tissue samples that doctors often use, so they can help personalize treatments for patients more effectively.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Redbud Labs, INC. NIH-funded |
| Lab location | 1 site (Durham, UNITED STATES) |
| Project start | September 16, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,238,908 |
| NIH project number | 2R44GM148126-02A1 |
| Project ID | NIH-10931835 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients whose tumor samples are preserved in FFPE format, particularly those with colorectal, lung, or melanoma tumors.
✕Less likely to help
Patients with fresh-frozen tissue samples or those whose tumors are not preserved in FFPE format may not benefit from this research.
What this research studies
This research focuses on enhancing the extraction of nucleic acids from fixed paraffin-embedded (FFPE) tissue samples, which are commonly used in clinical settings. The project aims to automate the extraction process using advanced microfluidic technology, making it more efficient and reliable compared to traditional manual methods. By improving the quantity and quality of nucleic acids extracted, this research could significantly aid in genomic sequencing, which is essential for personalized medicine. The approach involves developing a fully automated system that streamlines the sample preparation process.
Why it matters
Potential benefit: If successful, this research could lead to more accurate genomic analyses, improving clinical decision-making and patient outcomes in cancer treatment.
How similar studies have gone: Other research has shown promise in automating nucleic acid extraction from FFPE samples, indicating that this approach has potential for success.
Where this research is happening
-
Redbud Labs, INC.
Durham, United States Active
Researchers
- Principal investigator: Fisher, Jay Kenneth — Redbud Labs, INC.
- Study coordinator: Fisher, Jay Kenneth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.