Improving the extraction of genetic material from preserved tissue samples
Improving extraction success of FFPE samples with automated and reliable microfluidic sample preparation
This study is working on a new, easier way to get DNA and RNA from tissue samples that doctors often use, so they can help personalize treatments for patients more effectively.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Redbud Labs, INC. NIH-funded |
| Lab location | 1 site (Durham, UNITED STATES) |
| Project ID | NIH-10931835 on NIH RePORTER |
What this research studies
This research focuses on enhancing the extraction of nucleic acids from fixed paraffin-embedded (FFPE) tissue samples, which are commonly used in clinical settings. The project aims to automate the extraction process using advanced microfluidic technology, making it more efficient and reliable compared to traditional manual methods. By improving the quantity and quality of nucleic acids extracted, this research could significantly aid in genomic sequencing, which is essential for personalized medicine. The approach involves developing a fully automated system that streamlines the sample preparation process.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients whose tumor samples are preserved in FFPE format, particularly those with colorectal, lung, or melanoma tumors.
Not a fit: Patients with fresh-frozen tissue samples or those whose tumors are not preserved in FFPE format may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate genomic analyses, improving clinical decision-making and patient outcomes in cancer treatment.
How similar studies have performed: Other research has shown promise in automating nucleic acid extraction from FFPE samples, indicating that this approach has potential for success.
Where this research is happening
Durham, UNITED STATES
- Redbud Labs, INC. — Durham, United States (Active)
Researchers
- Principal investigator: Fisher, Jay Kenneth — Redbud Labs, INC.
- Study coordinator: Fisher, Jay Kenneth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.