Improving the efficiency of converting non-muscle cells into muscle cells
Enhance myogenic transdifferentiation efficiency using engineering approaches
['FUNDING_R21'] · UNIVERSITY OF MINNESOTA · NIH-10835117
This study is looking at new ways to turn regular body cells into muscle cells that can help with muscle repair and understanding muscle diseases, making the process quicker and safer for people who need better treatments for muscle disorders.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-10835117 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the process of converting non-muscle somatic cells into myogenic cells, which are essential for muscle repair and disease modeling. By using innovative engineering approaches, the project aims to increase the efficiency of this direct reprogramming technique, making it faster and safer for therapeutic applications. The researchers will utilize high-throughput screening methods to identify optimal conditions for reprogramming, while ensuring that the resulting muscle cells retain important characteristics related to aging and disease. This could lead to better treatments for muscle disorders and improved understanding of muscle diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with muscle disorders or myopathies who may benefit from advanced muscle cell therapies.
Not a fit: Patients with non-muscle related conditions or those who do not have muscle disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide patients with more effective and personalized therapies for muscle diseases.
How similar studies have performed: Other research has shown promise in similar approaches to direct reprogramming, indicating potential for success in this area.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHEN, WEI — UNIVERSITY OF MINNESOTA
- Study coordinator: SHEN, WEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.