Improving the effectiveness of HIV antibodies in the body
Official title: Mechanisms and means to improve HIV bnAb activity in vivo
Funded at Dartmouth College · NIH-10923364 · Data updated 2026-11-12
This study is looking at ways to make special antibodies that fight HIV work better, with the hope of finding new ways to help people prevent or control HIV infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | August 20, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $773,741 |
| NIH project number | 1R01AI183970-01 |
| Project ID | NIH-10923364 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals at high risk for HIV infection who may benefit from enhanced antibody therapies.
✕Less likely to help
Patients who are already living with HIV and are on antiretroviral therapy may not benefit directly from this research.
What this research studies
This research investigates how to enhance the activity of broadly neutralizing antibodies (bNAbs) against HIV by testing different strategies in animal models. The goal is to improve the ability of these antibodies to prevent HIV infection and control viral replication in the body. By refining the use of bNAbs, the research aims to provide a viable alternative to current HIV prevention methods, such as vaccines and small-molecule drugs. The study will monitor the effectiveness of these antibodies in delaying or preventing HIV infection in a controlled environment.
Why it matters
Potential benefit: If successful, this research could lead to more effective HIV prevention strategies that could significantly reduce the risk of infection.
How similar studies have gone: Previous research has shown promise in using broadly neutralizing antibodies for HIV prevention, but this approach is still being refined and tested.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Ackerman, Margaret E — Dartmouth College
- Study coordinator: Ackerman, Margaret E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.