Improving the effectiveness of HIV antibodies in the body
Mechanisms and means to improve HIV bnAb activity in vivo
['FUNDING_R01'] · DARTMOUTH COLLEGE · NIH-10923364
This study is looking at ways to make special antibodies that fight HIV work better, with the hope of finding new ways to help people prevent or control HIV infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DARTMOUTH COLLEGE (nih funded) |
| Locations | 1 site (HANOVER, UNITED STATES) |
| Trial ID | NIH-10923364 on ClinicalTrials.gov |
What this research studies
This research investigates how to enhance the activity of broadly neutralizing antibodies (bNAbs) against HIV by testing different strategies in animal models. The goal is to improve the ability of these antibodies to prevent HIV infection and control viral replication in the body. By refining the use of bNAbs, the research aims to provide a viable alternative to current HIV prevention methods, such as vaccines and small-molecule drugs. The study will monitor the effectiveness of these antibodies in delaying or preventing HIV infection in a controlled environment.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals at high risk for HIV infection who may benefit from enhanced antibody therapies.
Not a fit: Patients who are already living with HIV and are on antiretroviral therapy may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective HIV prevention strategies that could significantly reduce the risk of infection.
How similar studies have performed: Previous research has shown promise in using broadly neutralizing antibodies for HIV prevention, but this approach is still being refined and tested.
Where this research is happening
HANOVER, UNITED STATES
- DARTMOUTH COLLEGE — HANOVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ACKERMAN, MARGARET E — DARTMOUTH COLLEGE
- Study coordinator: ACKERMAN, MARGARET E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus