Improving the effectiveness of CAR-T cell therapy for cancer treatment.
Official title: Targeting metabolic stress response to improve CAR-T cell efficacy.
Funded at Methodist Hospital Research Institute · NIH-10945464 · Data updated 2026-11-12
This study is looking at ways to make CAR-T cell therapy work better for people with blood cancers by understanding how stress granules in T cells can affect their ability to fight tumors, with the hope of finding new strategies to improve treatment outcomes.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $415,257 |
| NIH project number | 1R21CA280566-01A1 |
| Project ID | NIH-10945464 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with B cell malignancies or those who have not responded well to existing CAR-T therapies.
✕Less likely to help
Patients with solid tumors that are not related to B cell malignancies may not benefit from this research.
What this research studies
This research investigates how to enhance the effectiveness of CAR-T cell therapy, a promising treatment for certain blood cancers. The focus is on understanding the role of stress granules in T cells, which can affect their performance against tumors. By examining how these stress granules contribute to T cell exhaustion, the researchers aim to find ways to improve CAR-T cell function. Patients may benefit from new strategies that could make CAR-T therapy more effective against solid tumors.
Why it matters
Potential benefit: If successful, this research could lead to improved CAR-T cell therapies that are more effective in treating various cancers.
How similar studies have gone: Previous research has shown promise in enhancing T cell therapies, but this specific approach targeting stress granules is relatively novel.
Where this research is happening
-
Methodist Hospital Research Institute
Houston, United States Active
Researchers
- Principal investigator: Min, Irene M. — Methodist Hospital Research Institute
- Study coordinator: Min, Irene M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.