Improving the diagnosis and treatment of sepsis in emergency departments
Official title: Diagnostic Safety and Quality Optimization in Sepsis (DISQOS)
Funded at University of Michigan at Ann Arbor · NIH-10931492 · Data updated 2026-11-12
This study is looking for better ways to help doctors quickly and accurately diagnose sepsis in emergency rooms, so patients can get the right treatment right away and stay safe.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 30, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $400,000 |
| NIH project number | 5R01HS029656-02 |
| Project ID | NIH-10931492 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who are hospitalized with suspected sepsis and are presenting to emergency departments.
✕Less likely to help
Patients who do not present with symptoms of sepsis or those who are not hospitalized may not benefit from this research.
What this research studies
This research focuses on enhancing the safety and quality of diagnosing sepsis, a life-threatening condition, in emergency departments. It aims to identify effective practices for accurately diagnosing patients who may have sepsis while minimizing the risks associated with misdiagnosis. By employing a mixed-methods evaluation approach, the research will develop a toolkit to help healthcare providers implement these practices effectively. The ultimate goal is to ensure that patients receive timely and appropriate treatment, reducing the chances of severe complications or death.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and timely diagnoses of sepsis, significantly improving patient outcomes and reducing mortality rates.
How similar studies have gone: Previous research has shown that improving diagnostic practices in emergency settings can lead to better patient outcomes, indicating that this approach has potential for success.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Taylor, Stephanie P — University of Michigan at Ann Arbor
- Study coordinator: Taylor, Stephanie P
Related research
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This research tests whether blocking MMP3 can protect the heart and improve survival during sepsis in adults.
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Sepsis patient care guided by Ugandan-wide immune profiling
A large NIH-funded study will map how the immune system behaves during sepsis in people in Uganda to improve personalized care for sepsis patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.